加拿大pc28

Xiang li

  • Tel: +86-021
  • Email: [email protected]
  • Address: Room 414, Building 2, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, China
  • Doctoral Supervisor and Principal Investigator (PI). My research focuses on the regulation of gene expression in immune cells and immunotherapy. My work has been published in prestigious international academic journals such as Nature (2024; 2026, accepted), Cell (2019), Nature Methods (2021), and Molecular Cell (2017, 2018).

Education and Research Experience

  • 2014–2020: University of Chinese Academy of Sciences, Ph.D. (Supervisor: Professor Ling-Ling Chen)
  • 2020–2021: Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Postdoctoral Fellow (Supervisor: Professor Ling-Ling Chen)
  • 2022–2026: Boston Children's Hospital, Harvard Medical School, Postdoctoral Fellow and Instructor (Supervisor: Professor Frederick W. Alt)
  • 2026–Present: School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Tenure-Track Associate Professor and Doctoral Supervisor

Research Interests

Gene Expression Regulation in Immune Cells

Develop novel high-throughput functional screening methods targeting the genome or transcriptome to systematically dissect the regulatory networks of gene expression in immune cells at both the DNA and RNA levels.

Immunotherapy

Develop novel gene therapies targeting 'key regulators' of immune homeostasis maintenance for immunotherapy

Selected Publications

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    Li X#, Zhang YW#, Hu HL#, Zhu T, Wesemann D, Lin X, Ye YX, Alt FW*. 2026. Linear RAG Scanning Mediates Editing of the Igκ Variable Region Repertoires. Nature. (Accepted)

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    Zhang YW#, Li X#, Ba ZQ, Lou JM, Gaertner KE, Zhu T, Lin X, Ye YX, Alt FW*, Hu HL#*. 2024. Molecular basis for differential Igk versus Igh V(D)J joining mechanisms. Nature. 630(8015):189-197

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    Li SQ#, Li X#, Xue W#, Zhang L#, Yang LZ, Cao SM, Lei YN, Liu CX, Guo SK, Shan L, Wu M, Tao X, Zhang JL, Gao X, Zhang J, Wei J, Li JS*, Yang L* and Chen LL*. 2021. Screening for functional circular RNAs using the CRISPR-Cas13 system. Nat Methods. 18(1):51-59

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    Liu CX#, Li X#, Nan F#, Jiang S, Xiang G, Guo SK, Xue W, Cui YG, Dong KG, Ding HH, Qu B, Shen N*, Yang L* and Chen LL*. 2019. Structure and degradation of circular RNAs regulate PKR activation in innate immunity. Cell. 177, 865-880

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    Li X#, Liu CX#, Xue W#, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L* and Chen LL*. 2017. Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection. Mol Cell. 67, 214-227 e217

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    Li X, Yang L* and Chen LL*. 2018. The Biogenesis, Functions and Challenges of Circular RNAs. Mol Cell. 71, 428-442. 

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    Li X, Zhang JL, Lei YN, Liu XQ, Xue W, Zhang Y, Nan F, Gao X, Zhang J, Yang L and Chen LL*. 2021. Linking circular intronic RNA degradation and function in transcription by RNase H1. Science China Life Sciences.64(11):1795-1809

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    Gao X#, Ma XK#, Li X, Li GW, Liu CX, Zhang J, Wang Y, Wei J, Chen J, Chen LL and Yang L*. 2022. Knockout of circRNAs by base editing back-splicing sites of circularized exons. Genome Biol. 23(1):16

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    Zhang Y#, Xue W#, Li X, Zhang J, Chen S, Zhang JL, Yang L* and Chen LL*. 2016. The Biogenesis of Nascent Circular RNAs. Cell Rep. 15, 611-624.

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    Tao X#, Zhai SN#, Liu CX#, Huang YK, Wei J, Guo YL, Li XQ, Li X, Yang L*, Chen LL*. 2025. Degradation of circular RNA by the ribonuclease DIS3. Mol Cell.85(8):1674-1685.e8

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