研究员
教育经历
科研经历
2022-06至今，上海交通大学，Bio-X研究院，研究员
2019-09至2022-06, 上海交通大学, Bio-X研究院, 副教授
2013-09至2019-09, 中科院上海生命科学研究院, 生化与细胞研究所, 副研究员
2010-09至2013-09, 香港科技大学生命科学部, 博士后, 导师: 张明杰院士
裂孔隔膜（slit diaphragm）组装的生化和结构基础；肾病综合征发病的分子机制；细胞连接，细胞极性和细胞迁移的结构生物学
突触发育过程的生化和结构机理；突触可塑性过程的分子机制；神经精神疾病的结构生物学基础
Zhang M#, Cao A#, Lin L#, Chen Y, Shang Y, Wang C, Zhang MJ, Zhu J*. (2023) Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs. Sci Adv. 10;9(19):eadf3295.
Gu J#, Peng R#, Guo C#, Zhang M, Yang J, Yan X, Zhou Q, Li H, Wang N, Zhu J*, Ouyang Q*. (2022) Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor. Nat Commun. 13(1):7176.
Shi Y#, Lin L#, Wang C*, Zhu J*. (2022) Promotion of row 1-specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia. Sci Adv. 8(23):eabn4556.
Lin L#, Shi Y#, Wang M, Wang C, Lu Q, Zhu J*,1, Zhang R*. (2021) Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep 34(8):108770. (1Lead Contact).
Wang M#, Lin L#, Shi Y, He L, Wang C*, Zhu J*. (2020) Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochem J 477(23):4623-4634.
Zhu J#,*, Zhou Q#, Xia Y, Lin L, Li J, Peng M, Zhang R*, Zhang M*. (2020) GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling. Mol Cell 79(5):782-796.e6.
Weng Z, Situ C, Lin L, Wu Z, Zhu J*, and Zhang R* (2019) Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun 10(1):51.
Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R* and Zhu J* (2018) Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling. J Am Soc Nephrol 29(9):2362-2371.
论文下载
支撑材料
论文下载