加拿大pc28

Ruizeng Yang^#, Liqiao Hu^#, Jing Wang^#, Jia Wang, Liang Yuan, Mengying Wu, Lingli He, Wentao Yu, Peihao Chen, Xiaoli Lu, Fangzheng Hu, Haijiao Zhang, Haoran Gao, Xiaodong Wang, Haoen Zhang, Yang Sun, Jinjin Xu, Jing Huang, Hu Zhou, Jidong Zhu, Fang Wei, Yunyun Jin, Yijun Gao, Qiang Fu, Xiangbing Qi*, Jing Yu*, Pilong Li*, Xiaojing He*, Lei Zhang*. Phase separation-based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression. Science Translational Medicine  2026 Apr 22;18(846): eadu0814. (cover story)

Zhiyun Ren^#, Yilin Zhao^#, Wentao Yu, Xia Zhang, Xiaoxuan Song, Yanling Bao, Meng Hu, Lishuang Chen, Hao Yang, Bingkai Cheng, Cong Liu, Yunyun Jin*, Lei Zhang*, Bo Sun*. VGLL4-driven TEAD4 multimerization orchestrates DNA binding and YAP recruitment. Nat Communications 2026 Apr 11. doi: 10.1038/s41467-026-71766-5.

Haoen Zhang^#, Zuoyun Wang^#, Xiaodong Wang, Wentao Yu, Guoying Zhang, Haijiao Zhang, Yi Lu, Yang Sun, Tiantian Lu, Xiaoyu Li, Ruizeng Yang, Jiaqi Sun, Jinjin Xu, Shuo Huang, Xueyan Ma, Jiale Ren, Nan Tang, Zhonghua Cheng, Jing Yu, Fang Wei, Hu Zhou, Jinsong Li, Jun Qin, Yunyun Jin* & Lei Zhang*. VGLL4 modulates Paneth cells and sustains intestinal homeostasis. EMBO Reports  2026 Mar;27(5):1353-1382

Dan Jiang, Pengyue Li, Yi Lu, Jiaxin Tao, Xue Hao, Xiaodong Wang, Wei Wu, Jinjin Xu, Haoen Zhang, Xiaoyu Li, Yixing Chen, Yunyun Jin*, Lei Zhang*. A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration. Nature communications  2025 Jan 10;16(1):570

Yang Sun, Henan Wei, Wentao Yu, Haoran Gao, Jinhui Li, Xiaoyu Li, Haijiao Zhang, Haoen Zhang, Sen Miao, Lihua Zhao, Ruizeng Yang, Jinjin Xu, Yi Lu, Fang Wei, Hu Zhou, Daming Gao, Yunyun Jin*, Lei Zhang*. The Actin Binding Protein Drebrin Disrupts NF2-LATS Kinases Complex Assembly to Facilitate Liver Tumorigenesis. Hepatology, 2025 May 1;81(5):1433-1451.

Lingli He^# , Liang Yuan^#, Wentao Yu,  Yang Sun, Dan Jiang, Xiaodong Wang, Xue Feng, Zuoyun Wang, Jinjin Xu, Ruizeng Yang, Wenxiang Zhang, Hua Feng, Hangzi Chen, Yi Arial Zeng, Lijian Hui, Qiao Wu, Yonglong Zhang,* & Lei Zhang*  A regulation loop between YAP and NR4A1 balances cell proliferation and apoptosis.  Cell Reports 2020, 33(3): 108284

Jinlong Suo^#,Xue Feng^#,Jiayi Li,Jinghui Wang,Zuoyun Wang*,Lei Zhang*, Weiguo Zou* VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances 2020, 6(43):eaba4147

Xue Feng^#, Tiantian Lu^#, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng*, Wei Tian* and Lei Zhang* The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice. Hepatology 2020 Jun;71(6):1988-2004

Xue Hao, Shimin Wang, Yi Lu, Wentao Yu, Pengyue Li, Dan Jiang, Tong Guo, Mengjie Li, Jinhui Li, Jinjin Xu, Wenqing Wu, Margaret S. Ho*, Lei Zhang*  Lola regulates Drosophila adult midgut homeostasis via non-canonical Hippo signaling. eLife, 2020, 9:e47542

Xue Feng^#, Zuoyun Wang^#, Fei Wang^#, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu* and Lei Zhang* Dual function of VGLL4 in muscle regeneration. The EMBO Journal, 2019,38(17): e101051